Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
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چکیده
منابع مشابه
Ultrastructural Modifications of Human Endometrium during the Window of Implantation
The endometrium is a highly dynamic tissue empowered with the capacity to undergo cyclic dramatic changes in response to ovarian steroid hormones, ultimately aiming to create a window of receptivity for blastocyst implantation. Intensive research has been performed to understand and establish morphological and molecular correlates of embryo implantation. However, it still remains a biological m...
متن کاملThe family of pro-hormone and pro-protein convertases.
R. 1’. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6388-6392 38. FourniC-Zaluski? M. C., Chaillet, P., Rouboutou, R., Coulaud, A., ChCrot, P., Waksman, G., Costentin, J. and Roques, B. P. (1984) Eur. J. Pharmacol. 102, 525-528 39. Hourgoin, S., I,e Hars, D., Artaud, F., Clot, A. M., Bouboutou, R., FourniC-Zaluski, M. C., Roques, B. P., Hamon, M. and Cesselin. F. (1986) J. Pharmacol. Exp. Ther. 238...
متن کاملProprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation.
Establishment of endometrial receptivity is vital for successful embryo implantation. Proprotein convertase 5/6 (referred to as PC6) is up-regulated in the human endometrium specifically at the time of epithelial receptivity. PC6, a serine protease of the proprotein convertase family, plays an important role in converting precursor proteins into their active forms through specific proteolysis. ...
متن کاملThe Actors of Human Implantation: Gametes, Embryo, Endometrium
The success of pregnancy depends on a receptive endometrium, a normal blastocyst, a synchronized cross-talk at the maternal–fetal interface at the time of implantation, and finally a successful placentation and remodeling of uterine vasculature. In routine, less than 5% of oocytes collected in in vitro fertilization (IVF) cycles and only 20 to 25% of embryos transferred lead to a birth. Implant...
متن کاملThe tightly regulated copper window in yeast.
The two opposing yeast copper regulators, Ace1 and Mac1, were converted into two fluorescent probes, Ace1-FRET and Mac1-FRET, which selectively and sensitively respond to Cu(+). The Cu(+)-binding curves obtained for both regulators as well as for the copper storage proteins Cup1 and Crs5 show that free copper(i) is maintained in a narrow window inside yeast.
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ژورنال
عنوان ژورنال: Reproduction
سال: 2007
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-06-0285